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SIBO “Supplement” Spotlight: EnteraGam

September 2, 2017 By Riley 18 Comments

Have you heard of EnteraGam?  It’s a medical food designed for the management of IBS-D.  But it could also potentially work for some people with IBS-C and SIBO.  Or at least that’s what I have seen.  Let me explain…

Personal Experience

I first heard about EnteraGam when I was working as an assistant to a doctor in the IBS/SIBO world.  EnteraGam’s manufacturer wanted doctors to know about it.  So they reached out to doctors to see if they wanted to receive free samples to give to patients.

Then, I didn’t really hear a whole lot about EnteraGam for a while.  Until a doctor recommended it for me.  And then another.  I had told the doctor that the bovine colostrum supplement (learn more about colostrum here) I had used on and off successfully for the past few years was no longer available.  New regulations made it so that the clean colostrum product (from New Zealand) I knew and loved wasn’t an option for me.  I tried others, but wasn’t pleased.  Then EnteraGam came into the picture.  The doctor basically described it as colostrum on steroids (not the bad kind, just a figure of speech)!

And let me tell you, it sure did act like colostrum on steroids for me.  And I had only been prescribed half a packet daily (2.5 grams), which is a dose much smaller than typically recommended.  There were a couple things that happened.  First, the annoying eye twitching that I couldn’t seem to make go away for a few weeks (through stress reduction, plenty of sleep, electrolytes), miraculously went away when I began EnteraGam.  But even more exciting was that my tolerance to a variety of foods increased, my skin looked better than ever, and digestive symptoms such as abdominal tenderness, gas, and constipation went away (although not permanently, but for a few days at a time without another dose).

I would be remorse if I failed to tell you the “not as pleasant” symptoms I experienced and how I overcame them.  After a few days of taking EnteraGam, my digestive system was feeling really good, but I continued taking it anyways.  Those nights, after I took it, I experienced insomnia and a sensation of rapid heart rate.  I was able to fix this problem by reducing the dose to one-third of a packet.  Pro tip: there are a total of 3 teaspoons per packet, so you can measure out in half teaspoon increments to obtain half or one-third of a packet.

Now, I take EnteraGam on an as needed basis.  I have noticed that the effects are not quite as powerful as when I first started taking it (kind of the story of my life with pretty much any substance that has antimicrobial properties).  But I think it could be a good option for many people out there suffering from IBS, so I wanted to share my story.

In order to obtain EnteraGam (and at an affordable price since insurance doesn’t cover medical foods), my doctor sent my prescription to Foundation Care Pharmacy.  I then received a call from Foundation Care Pharmacy, paid the $78 for the box of packets, and a couple days later, EnteraGam arrived by mail at my house.

What is a Medical Food?

EnteraGam is technically a “medical food”, not a supplement.  But “SIBO Supplement Spotlight” was just too catchy.  SIBO Medical Food Spotlight just doesn’t quite roll off the tongue in the same way.

According to the FDA, a medical food is “a food which is formulated to be consumed or administered enterally under the supervision of a physician and which is intended for the specific dietary management of a disease or condition for which distinctive nutritional requirements, based on recognized scientific principles, are established by medical evaluation” [1].

Let’s break that down:

  • Enterally = administered through the digestive tract (rather than through the vein, for example)
  • Supervision of a physician = you need a prescription to get it (although “medical foods are not required by federal law to be dispensed by prescription” [1])
  • Specific dietary management = it isn’t just any old food, but instead, it is specially formulated.  It isn’t quite food, but isn’t quite a drug (in the pharmaceutical sense).  It’s somewhere in between- more like a purified food ingredient making it more natural than most drugs (which are often unnatural molecular formulations), but not as natural as food.

As Ciampa et. al so elonquently put it “medical foods, or purified food ingredients, are based on the idea that diseases can be safely managed with compounds that humans have adapted to over millennia” [2].

Other examples of medical foods that you may have heard of include: VSL#3 (a strong probiotic) and Vivonex (an elemental diet formula commonly used for SIBO).

Primary Uses of EnteraGam

The majority of the research behind EnteraGam examines its use for individuals with IBS-D or HIV-associated enteropathy.  There is also research on its use in inflammatory bowel disease (IBD).

If you would like to look into its use in these conditions, I recommend searching for “serum-derived bovine immunoglobulins” in PubMed.  Some articles are available as “full text”, while others you can only read the abstract (summary) and must pay to access the full article.

I will focus the rest of this blog post mostly on potential alternative uses for EnteraGam, especially as it relates to IBS-C and SIBO.

What is in EnteraGam?

EnteraGam consists primarily of protein.  In fact, it’s greater than 90 percent protein and most of that protein is in the form of immunoglobulin G (IgG).  IgG plays an important role in immune health.  EnteraGam also contains small amounts of IgM and IgA (which are other immune factors).

It comes from a bovine (cow) source.  So if someone is vegan, vegetarian, or allergic to beef, EnteraGam would not be appropriate.

EnteraGam does not contain whey, casein, or lactose [4].  These are the proteins and sugar in milk and other dairy products that can cause digestive upset for some individuals.

Other ingredients in EnteraGam include dextrose and trace amounts of sunflower lecithin.  Dextrose is a sugar that tends to be well-tolerated by individuals with IBS and SIBO.  It is likely added to this product for palatibility.  Pure protein tastes pretty gnarly.  Sunflower lecithin is a common ingredient in food and supplement products and is even sometimes consumed as a supplement on its own.

Bovine Colostrum vs. EnteraGam

Sometimes when individuals well-versed in the nutritional supplement community hear about EnteraGam, they wonder- “why not just take colostrum?”

Well, EnteraGam is much more potent.  Bovine colostrum contains between 3 and 25 percent immunoglobulin G (depending on the product), while EnteraGam contains greater than 50 percent.

Additionally, a study done on baby cows revealed that bovine serum-derived IgG was more effective than colostrum at reducing the number of treatments needed for illness.

Check out my blog post on bovine colostrum if you would like to learn more about this supplement.

How Does EnteraGam Work?

It is not completely understood how and why EnteraGam works for the different conditions it benefits, but a variety of mechanisms of action have been proposed.

Theorized mechanisms of action:

  • Binding microbial components (working in a similar way as our bodies own production of secretory IgA)- such as lipopolysaccharide (LPS), peptidoglycan, flagellin, and others
  • Supporting immune balance in the GI tract
  • Improved nutrient uptake (of beneficial amino acids such as arginine, glutamine, leucine, tryptophan, and proline)
  • Improving gut barrier function by increasing expression of tight junction proteins zonulin and occludin (in layman’s terms- healing leaky gut!)

Safety of EnteraGam

A study was conducted on healthy individuals in order to assess EnteraGam’s safety profile.  The study utilized doses as high as 20 grams (that’s a high dose- 4 packets!) of EnteraGam and monitored for a variety of factors.

No severe adverse events were reported, but some individuals experienced mild or moderate adverse events.  The most common adverse event was abdominal cramping, followed by constipation, bloating, diarrhea, flatulence, abdominal pain, and nausea.  Only 2 of the 40 subjects decided to withdraw from the study due to adverse events.

The study also looked at whether there were any signs of EnteraGam entering the bloodstream as it is not supposed to.  There was only one case showing entrance into the bloodstream, but researchers theorized that it was most likely due to an error in the sampling.  The idea is that EnteraGam is supposed to remain in the digestive tract and be excreted in feces.

Clinical research shows that approximately 2-5% of individuals experience adverse events from EnteraGam [5].

Published Case Report Using EnteraGam in IBS-D, IBS-C, IBS-M, and IBS-U (Bloating)

A published case report utilizing EnteraGam (5 or 10 grams daily) for 14 individuals with IBS revealed the following results:

  • IBS-D (7 patients): improvement in abdominal pain, diarrhea, urgency, improved stool consistency, incontinence
  • IBS-C (2 patients):
    • Patient 1- ineffective
    • Patient 2- improvement in bloating, distension, and nausea
  • IBS-M (2 patients):
    • Patient 1- improvement in bloating
    • Patient 2- improvement in bloating, distension, bowel movements
  • IBS-U/bloating (3 patients):
    • Patient 1- ineffective
    • Patient 2- resolution of symptoms (bloating, distension, flatulence, abdominal pain)
    • Patient 3- resolution of symptoms (gas, bloating, abdominal pain)

Survey Results of IBS & IBD Patients Using EnteraGam

A survey was distributed to more than 14,000 individuals who were prescribed EnteraGam.  Of those individuals, 595 returned surveys that could be evaluated.  A variety of questions were asked, but some with the most promising results were the following [7]:

  • Prior to using EnteraGam, 88% of respondents indicated that their condition prevented them from doing things they enjoyed.  Of those individuals, 94% reported that after treatment with EnteraGam, it had allowed them to get back to activities they enjoyed.
  • Prior to using EnteraGam, 58% of respondents indicated that their condition prevented them from doing their job.  Of those individuals, 95% reported that EnteraGam helped them to manage their condition.
  • 73% of survey respondents desired to continue taking EnteraGam.

Now, while these results are super promising, we should keep in mind that in general, people tend to respond to surveys when they are highly satisfied or highly unsatisfied with a product, service, etc.  So it is possible that these results are slightly skewed from reality.

Conclusion

I compiled this article because I know what it is like to feel miserable and not feel like you have any options.  Medical research often takes decades to begin being implemented into practice.  If you are an individual suffering from IBS, IBD, HIV-associated enteropathy, or another condition that you think could be helped by using EnteraGam, it might be worth talking to your doctor and perhaps providing a copy of some of the below relevant research articles if your doctor is not up to date on the topic.

References

[1] FAQs About Medical Foods.  Food & Drug Administration (FDA).  Available at: https://www.fda.gov/downloads/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation/UCM500094.pdf

[2] Ciampa BP, Reyes ramos E, Borum M, Doman DB. The Emerging Therapeutic Role of Medical Foods for Gastrointestinal Disorders. Gastroenterol Hepatol (N Y). 2017;13(2):104-115.

[3] Good L, Rosario R, Panas R. New therapeutic option for irritable bowel syndrome: serum-derived bovine immunoglobulin. World J Gastroenterol. 2015;21(11):3361-6.

[4] Shaw AL, Mathews DW, Hinkle JE, et al. Absorption and safety of serum-derived bovine immunoglobulin/protein isolate in healthy adults. Clin Exp Gastroenterol. 2016;9:365-375.

[5] Van arsdall M, Haque I, Liu Y, Rhoads JM. Is There a Role for the Enteral Administration of Serum-Derived Immunoglobulins in Human Gastrointestinal Disease and Pediatric Critical Care Nutrition?. Adv Nutr. 2016;7(3):535-43.

[6] Shaw AL, Tomanelli A, Bradshaw TP, Petschow BW, Burnett BP. Impact of serum-derived bovine immunoglobulin/protein isolate therapy on irritable bowel syndrome and inflammatory bowel disease: a survey of patient perspective. Patient Prefer Adherence. 2017;11:1001-1007.

Filed Under: Bridgetown Nutrition Blogs Tagged With: Enteragam, IBS, leaky gut, SIBO

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Reader Interactions

Comments

  1. Patrik says

    November 6, 2017 at 1:55 pm

    Hi Riley!
    Are you still taking this supplement? What is your experience now when some more time has passed?
    Thanks! / Patrik

    Reply
    • Riley says

      November 10, 2017 at 10:57 am

      Hi Patrik,

      Great question! I am no longer taking it. I stopped taking it because it was actually starting to make things work a little too well (causing insomnia/anxiety which is also what happens if I take too much colostrum or resolor when I am already feeling fine). I think it may have actually had a somewhat lasting positive effect in terms of my immune function and intestinal permeability and therefore I just stopped needing it. That’s my best guess, anyhow!

      Reply
      • Patrik says

        November 10, 2017 at 1:59 pm

        Ok! I guess that is a good thing, in a way. It sounds like something to try, at least for a period anyway.
        Thanks! Patrik

        Reply
  2. Karl Wolters says

    January 14, 2018 at 4:36 am

    Hi Riley,

    would you say that it would cause anxiety now right away (as if your body is now sensitive to it) or would it just always push so that it would help if you are bloated and slow but would make u anxious if you are already fine?

    Reply
    • Riley says

      January 16, 2018 at 11:22 am

      Great question! I am not completely sure because I haven’t tried it recently, but I suspect that it would be fine if I was symptomatic but cause anxiety if I was already fine.

      Reply
  3. Alison Ormiston says

    April 18, 2018 at 6:36 am

    I take it daily with zero negative side effects. It has helped me tremendously. I do one full packet daily and have been for almost a year. I’m taking it while I try to figure out the root cause of my symptoms as it doesn’t cure you, it just puts a much needed band-aid on the symptoms and allows me to live better. It’s funny how we are all so different and these treatments work in different ways for each person. Good luck!!

    Reply
    • Riley says

      April 18, 2018 at 8:23 am

      Thanks so much for sharing this info with us! So glad you have a tool that has helped you so much!

      Reply
  4. Lisa says

    January 19, 2019 at 12:37 pm

    I have Chronic Lyme with coinfections Babesia and Bartonella. Will this be helpful for me even if I don’t have issues with IBD?

    Reply
    • Riley says

      January 20, 2019 at 1:47 pm

      It is tough to know for sure- I would say it has potential to help due to its immune-supporting properties, but it is best to ask your doctor about whether it would be helpful in your particular situation.

      Reply
  5. Kristy says

    May 19, 2019 at 7:59 am

    I started taking EnteraGam a few days ago and noticed I am now having mild hot flashes. Could EnteraGam have estrogenic effects on my 53-year-old body?

    Reply
    • Riley says

      May 21, 2019 at 7:18 pm

      Hi Kristy, I imagine it is possible, but I did not find any research to support or deny that theory. Let me know if you are able to find more info!

      Reply
  6. Michael says

    July 26, 2019 at 5:04 pm

    Hi Riley, How long did you take it for (1 month 3 months, etc.) and 1 packet per day, I presume? It would be nice to know how you knew you no longer needed it too. Thanks,

    Reply
    • Riley says

      August 4, 2019 at 8:15 pm

      Hi Michael, it’s been so long that I don’t quite remember the details. I did not take a full packet per day. I believe I took 1 1/2 tsp per day. And when I no longer felt I needed it, I believe that was because I was starting to feel really hungry. I suspect it was actually causing food to move through my system too quickly without being absorbed. Other supplements that work for me have a similar effect if I take too much. Hope that helps!

      Reply
  7. Vivek says

    November 19, 2019 at 1:19 pm

    Would you know of any vegan alternatives for Enteragram (SBI)?

    Reply
    • Riley says

      November 20, 2019 at 9:38 am

      I do not, sorry. Good luck!

      Reply
  8. Kate says

    October 13, 2020 at 9:44 pm

    Thanks for this summary! I’m helping a family member who was prescribed EnteraGam, and she’s getting really nauseated taking it. Do you have any suggestions of what’s best to mix it with to make it easier to take/avoid nausea?

    Reply
    • Riley says

      October 14, 2020 at 6:09 pm

      Hi Kate, I’m not sure of something it could be mixed with to help with nausea. Ginger tea can help with nausea though. Have you already reached out to the prescribing physician? One idea to run by them would be reducing the dose and slowly working up to the full dose, in case the reaction is due to a die-off effect. Hope that’s helpful!

      Reply
      • Kate says

        October 15, 2020 at 6:48 am

        Thanks, Riley! She actually started having a sip of water and then a ginger candy right after taking it, and that’s helped some. We’ll try adding the tea too!

        I hadn’t thought about asking for a dosage change. We’re hoping she’ll be able to tolerate the full dose now to get benefits sooner, but if not, we’ll definitely ask her doctor about that!

        Thanks so much!

        Reply

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Welcome! I'm Riley- master's degree trained nutritionist. Dedicated to helping you overcome digestive (IBS/SIBO/SIFO) & related issues. Just like I have. I share flavorful, healthful, mostly low FODMAP recipes that go above & beyond- gluten-free, dairy-free (except butter/ghee), soy-free, & easy on the oats & eggs! Newer recipes are less likely to be low FODMAP as I continue to heal and expand my diet. I want to help you live a healthier & happier life. Read More…

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